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Grandma’s Best Meatloaf Recipe

Close up of slices of Grandma's Best Meatloaf Recipe

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Whenever I think of good old-fashioned comfort food I think of Grandma’s Best Meatloaf Recipe. Probably because it reminds me of my childhood and growing up on a farm. I vividly remember helping my mother make meals for our family. Meatloaf was one of our favorites.  

My mother has always been an avid gardener and therefore we raised the majority of our own food. Along with having three vegetable gardens we also raised cattle, pigs, chickens, and ducks. That translated into our kitchen producing a wide variety of homemade entrees, side dishes, desserts, and treats that seemed to satisfy everyone’s palate. 

I didn’t truly appreciate all of that marvelous, healthy, fresh food as a child. However, as an adult, it finally dawned on me the value of such a wholesome beginning. In other words, I certainly do appreciate how healthy my childhood diet was and consequently, a healthy diet has carried over into my adulthood. 

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Old-Fashioned Goodness

In my option there literally are no substitutes when it comes to good old-fashioned comfort foods. Somehow they seem to always hit the spot! (In other words… grandmas usually rock in the kitchen!)

Grandma’s Light-as-a-Feather Doughnuts

For example, some of our favorites are: 

As previously mentioned, one of our favorite old-fashioned meals is meatloaf with a side salad, mashed potatoes with gravy, fresh garden green beans with bacon. And, for the finale, a yummy skillet pie with a big scoop of ice cream. 

Ground Beef + Sausage

Grandma’s Best Meatloaf Recipe begins by combining 1 pound lean ground beef and 1/2 pound seasoned ground sausage – your choice of mild, medium, or hot. For a gluten-free version simply use a gluten-free brand of sausage. 

Other Ingredients

Secondly, add dried bread crumbs, onion, eggs, milk, ketchup, Worcestershire sauce, dried mustard, basil, oregano, sea salt, and black pepper to the meat mixture. Mix until all of the ingredients are well combined. 


Place the meat mixture into a 9.25 x 5.25 x 2.75 inches (23 x 13 x 7 cm) loaf pan and bake for 45 minutes in a preheated oven set to 350 degrees F. I like to use a two-piece loaf pan because the bottom pan catches the excess fat drippings and therefore you can easily discard the excess grease.


Meanwhile, make the glaze which is a mixture of ketchup, dark brown sugar, dried mustard, and Worcestershire sauce. You certainly don’t want to miss this step because the glaze adds a hint of sweetness to the meatloaf which is absolutely delightful.  

The next step is to brush the glaze mixture evenly over the top of the hot meatloaf then bake it for another 15 to 20 minutes.


Finally, remove the meatloaf from the oven and let it sit for 5 minutes then slice, serve, and enjoy! 

Freezer Friendly

You should also note that you can freeze the meatloaf for use later. Normally I freeze slices rather than the whole entire loaf. That way I can thaw the exact amount of servings I need. 

Slices of Grandma's Best Meatloaf Recipe

Also, remember that it’s easy to make this meatloaf recipe gluten-free

Grandma's Best Meatloaf Recipe
Yield: Serves 6 - 8

Grandma's Best Meatloaf Recipe

Prep Time: 15 minutes
Cook Time: 1 hour
Additional Time: 5 minutes
Total Time: 1 hour 20 minutes

Grandma's Best Meatloaf is a good old-fashioned recipe and the epitome of comfort food. It's also easy to make gluten-free.


  • 1 pound lean ground beef
  • 1/2 pound seasoned ground sausage - your choice of mild, medium, or hot - (GF Option - use a gluten-free brand)
  • 1/2 cup dried bread crumbs (GF Option - use gluten-free bread crumbs)
  • 2 eggs, slightly beaten
  • 1/2 cup onion, chopped
  • 1/2 milk
  • 1/2 cup ketchup
  • 1 1/2 Tablespoons Worcestershire sauce (GF Option - use a gluten-free brand)
  • 1 teaspoon dried mustard
  • 1 Tablespoon basil, fresh or dried
  • 1 Tablespoon oregano, fresh or dried
  • 1 teaspoon sea salt
  • 1 teaspoon ground black pepper
  • 1/2 cup ketchup
  • 2 Tablespoons dark brown sugar
  • 1/4 teaspoon dried mustard
  • 2 teaspoons Worcestershire sauce (GF Option - use a gluten-free brand)


  1. Preheat oven to 350 degrees F.
  2. Place all of the ingredients for the meatloaf into a large mixing bowl. Stir until mixture is well combined. Place mixture into a loaf pan. Bake for 45 minutes.
  3. In the meantime, whisk together the ingredients for the glaze in a small mixing bowl. Brush mixture evenly over the top of the hot meatloaf. Bake for another 15 to 20 minutes.
  4. Remove from the oven and let the meatloaf sit for 5 minutes. Slice and serve.

There are many reasons to love this recipe, but to sum it up, it’s just plain delicious! 

What is your favorite comfort food? 


More great ideas: 

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